LIFTUP: Effective Cortical Stimulation

Brain stimulation has recently seen more acceptance among the non-clinical research communities, especially since the Food and Drug Administration of approved the use of Deep Brain Stimulation, vagus nerve stimulation, and repetitive transcranial magnetic stimulation to treat brain disorders. However, many of these technologies are painful to use, such as rTMS, and others require invasive brain surgery DBS.

Our new brain stimulation method called Low-Intensity Focused Transcranial Ultrasound Pulsation (LIFTUP), we now have the ability to utilize ultrasound to non-invasively stimulate cortical brain regions through the skull and into the human brain, and it can be easily paired with EEG or FNIR recording technology.


Here we offer an array of research to help familiarize yourself with Ultrasound stimulation:


Although the first attempts to study the effect of US on neuronal tissue began nearly 80 years ago, systematic scientific exploration of this field did not start until the 1950s. At that time, several articles, in different languages, described the effect of US on neuronal tissues, with the most relevant English language articles arising from Fry’s laboratory. The studies demonstrated that US could induce reversible physiologic effects on nervous tissue, which ranging from increased activity to reversible suppression of visual evoked potentials. Notably, Fry’s studies documented both excitation and inhibition of neuronal tissue without concomitant histologic changes in the sonicated area.


Berkeley Ultrasound has developed a medical technology platform based on proprietary Low Intensity Focused Transcranial Ultrasound Pulsation (LIFTUP) technology to modulate the brain function non-invasively without any harmful or irreversible effects on the brain and body.